FIGURE

Figure 6

ID

ZDB-FIG-231030-122

Publication

Huttner et al., 2023 - Loss of Sec-1 Family Domain-Containing 1 (scfd1) Causes Severe Cardiac Defects and Endoplasmic Reticulum Stress in Zebrafish

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Figure 6

scfd1 deficiency leads to systolic dysfunction in adult zebrafish hearts. Scatter graphs showing high-frequency echocardiography data from heterozygous hah^vcc43+/− and scfd1^vcc44+/− mutants aged 9–15 months. Heart rate and ventricle end-diastolic volume (EDV), normalized to body surface area, (BSA) were normal, while ventricle end-systolic volume (ESV), normalized to BSA, was increased. Ventricular ejection fraction (EF) and global longitudinal strain (GLS) were reduced in hah^vcc43+/− and scfd1^vcc44+/− mutants in comparison to wildtype (+/+). Maximal atrial area (AA) was increased in scfd1^vcc44+/− mutants. Significant one-way ANOVA and multiple comparisons p-values stated. Significance if p < 0.05. Created with BioRender.com.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	scfd1^vcc43/+ scfd1^vcc44/+
Observed In:	heart contraction
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Cardiovasc Dev Dis