FIGURE

Figure 2

ID

ZDB-FIG-230814-239

Publication

De la Cruz et al., 2023 - Pharmacological Screening of Kv7.1 and Kv7.1/KCNE1 Activators as Potential Antiarrhythmic Drugs in the Zebrafish Heart

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Figure 2

I_Kr and I_Ks inhibitors prolong zebrafish AP. (A) Representative zebrafish AP traces before (black) and after (red) applying E4031 (10 µM). (B) ΔAPD80 (%) after (red) applying E4031 (10 µM), as measured at different recording times (10, 20, and 30 min after application of the drug). (C) ΔAPD(%) produced by the drug measured for the APD25, APD50, APD80, and APD90. (D) Effect of the drug on phase 3 of the AP. APD80–APD25 under control conditions and after E4031 application. (E–H) The same as in (A–D) but for the I_Ks inhibitor chromanol 293B (100 µM). (I–L) The same as in (A–D) but for the I_Ks inhibitor JNJ303 (10 µM) (mean ± SEM; * p < 0.05 vs. control conditions, ^Φp < 0.05 APD80 time data average vs. control condition). Each symbol in panels D, H, and L represent data from a different experiment.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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