FIGURE

Figure 7

ID

ZDB-FIG-230814-22

Publication

Yang et al., 2023 - cdh23 affects congenital hearing loss through regulating purine metabolism

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Figure 7

ATP compensation partially recovered the cdh23 mutant phenotype. (A) The hair cells in ear and around the eye can uptake YO-PRO-1 dye while the cdh23 mutant embryos cannot (C), (A’): the hair cells in the control inner ear, (C’): the hair cells in cdh23 mutant embryos. The ATP supply of control (B), hair cells were specifically stained by YO-PRO-1 dye, in cdh23 mutant (D), after ATP adjunction, the function of hair cells in inner ear were partially recovered, while the hair cells around the eye still impaired. (A’–D’) is the otic regions of (A–D), respectively. (E) The numbers of hair cells in each group, ns, no significant difference, ***, significant difference, p<0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TU cdh23^{zf4078/zf4078} (TU) cdh23^{zf4079/zf4079} (TU)
Condition:	chemical treatment by environment: ATP
Observed In:	neuromast hair cell purinergic nucleotide receptor signaling pathway
Stage:	Day 6

Phenotype Detail

Acknowledgments

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