FIGURE

Figure 3

ID

ZDB-FIG-230814-18

Publication

Yang et al., 2023 - cdh23 affects congenital hearing loss through regulating purine metabolism

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Figure 3

Knock out of cdh23 resulted in impaired hair cell function. The function of hair cells is evaluated by performing a YO-PRO-1 uptake experiment at 6 dpf. The ear hair cell (A) and lateral neuromast (B) uptake YO-PRO-1, while in the cdh23 homozygous mutant, the ear hair cell (C) and lateral neuromast (D) (arrow) do not have YO-PRO-1 fluorescence signal. (E) Genotyping results confirmed that the embryos with impaired function of hair cells are homozygous mutants. (F) The numbers of hair cells in each group, ***, significant difference, p<0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cdh23^{zf4078/zf4078} (TU) cdh23^{zf4079/zf4079} (TU)
Observed In:	auditory receptor cell purinergic nucleotide receptor signaling pathway neuromast hair cell purinergic nucleotide receptor signaling pathway
Stage:	Day 6

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.