FIGURE

Fig. 1

ID

ZDB-FIG-230727-6

Publication

Lucianò et al., 2023 - Exploring association of melanoma-specific Bcl-xL with tumor immune microenvironment

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Fig. 1

A) Representative images of immunohistochemical analysis of F4/80, CD206 and Bcl-xL expression in melanoma control (Mneo) and Bcl-xL overexpressing (Mxl90) tumour-bearing mice, performed 30 days after subcutaneous cell injection (20X magnification), and B) relative quantification of peritumoral (PT) and intratumoral (IT) macrophage infiltration by F4/80 and CD206 staining. The results are reported as mean score: score 0, no detectable infiltrate; score 1, low infiltrate; score 2, moderate infiltrate; score 3, high or very high infiltrate. p-values were calculated between control and Bcl-xL overexpressing tumours. C) Representative images of Mneo and Mxl90 cells 5 days after injection in the yolk sac of 2 days post fertilization Tg (mpeg1: Cherry/tnfa: GFP) zebrafish larvae, and D) relative quantification of M1 (mCherry+/eGFP+) and M2 (mCherry+/eGFP-) macrophages recruitment in the tail. B,D) Each dot (•) indicates an experimental point, *p < 0.05, ***p < 0.01; ns, no significant differences

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Exp. Clin. Cancer Res.