FIGURE

Figure 6

ID

ZDB-FIG-230526-53

Publication

Pogoda et al., 2023 - Direct BMP signaling to chordoblasts is required for the initiation of segmented notochord sheath mineralization in zebrafish vertebral column development

Other Figures

All Figure Page

Back to All Figure Page

Figure 6

RA can promote notochord sheath mineralization independently of BMP signaling at later stages of vertebral column formation. (A–D) Blockage of BMP signaling with synchronous activation of the RA pathway from six to eight dpf results in larvae with less severe disrupted notochord sheath mineralization while chordoblasts show clear marks of RA responsiveness (decreased Tg(R2-col2a1a:egfp) activity and less distinct cellular morphology). Lateral views of transgenic zebrafish larvae shown in merged transmitted and fluorescent light channels with tissue staining, genotypes and treatments as indicated at an age of 8dpf (A–D). Heat-shocks were performed once a day for 45 minutes at 40°C. Arrows in (D) point at zones of ectopic mineralization. Scale bars: 150 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Endocrinol (Lausanne)