FIGURE

Figure 4

ID

ZDB-FIG-230430-64

Publication

Mignani et al., 2023 - Deficiency of AP1 Complex Ap1g1 in Zebrafish Model Led to Perturbation of Neurodevelopment, Female and Male Fertility; New Insight to Understand Adaptinopathies

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Figure 4

Histological analysis of intestinal epithelium in adult fish. (A) Growth curve of ap1g1^+/+ and ap1g1^+/−. Body weight (in gr) was measured at different ages of adult life from 3 to 18 months. Both males’ and females’ ap1g1^+/− body weight is significantly lower compared to ap1g1^+/+. Statistical significance was determined by multiple t-test comparing each age group. For each group, 10 individuals were used and data was derived from two different experimental groups. (B) Histological analysis of ap1g1^+/+ and ap1g1^+/− intestinal mucosa with abnormal epithelium at the villous tips and reduced height of villi in the heterozygous mutant at 9 months age-old compared to wild-type homozygous fish. Scale bar = 100 μm Abbreviations: im: intestinal mucosa; gc: globet cells.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.