FIGURE

Fig. 2.

ID

ZDB-FIG-230219-16

Publication

Blum et al., 2023 - Localized heterochrony integrates overgrowth potential of oncogenic clones

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2.

Long bone overgrowth is caused by PI3K/AKT overactivation in mesenchymal derivatives. PI3K/AKT mosaic overactivation results in an early overgrowth phenotype in the fin endoskeleton. (A,B) In vivo confocal imaging of chondrocytes (A) marked by Tg(sox10:DsRed) (magenta) and osteoblasts (B) marked by Tg(sp7:mCherry) (magenta) in late larval stages reveals localized skeletal overgrowth in median fins of akt1^E18K-GFP (green) and myr-p110-GFP (green) mosaic larva overlapping with GFP⁺ cells. Boxed areas are at high magnification, showing that akt1^E18K-GFP and myr-p110-GFP colocalize with chondrocytes and osteoblasts. Asterisks indicate overgrown bones. Arrowheads indicate GFP⁺ chondrocytes in A and GFP⁺ osteoblasts in B. SL, standard length in mm. Scale bars: 100 μm; high-magnification images: 25 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.