FIGURE

Fig. 2

ID

ZDB-FIG-230120-10

Publication

Quadri et al., 2021 - Activation of PKG restricts melanoma growth and invasion by interfering with the EGF/EGFR pathway

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Fig. 2

Cell viability after treatment with cGMP analogs in melanoma spheroids and human melanocytes. (a) Dose‒response relationships of melanoma cell spheroids viability after exposure to different doses of PA4 and PA5 for 24 h. Values of NT cells were set as 100% of cell viability. (b) Cell viability in human metastatic melanoma spheroids treated with PA5 (250 nM) for 24 h. Values of NT cells were set as 100% of cell viability. (c) Viability time course of melanoma cell line‒derived spheroids treated with PA5 (250 nM). Cell viabilities at each time point were expressed as a percentage compared with that of time 0. (d) PA5 toxicity was evaluated in human primary melanocytes by MTT assay. Values of NT cells were set as 100% of cell viability. Data represent means ± SD of triplicate determinations. Student’s t-test was applied for statistical analyses of PA5-treated samples compared with NT. ∗∗P < 0.01; ∗0.01 < P < 0.05. h, hour; NT, not treated; PA, protein kinase G activator.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Invest. Dermatol.