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Fig. 3

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ZDB-FIG-221214-350

Publication

Truong et al., 2020 - The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity

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Fig. 3

Comparison of flame retardant toxicity to other high throughput assays.

The lowest effect concentration (LEC), point of departure (POD), and benchmark dose (BMD) for 12 FRC that were previously assessed in in vitro models, zebrafish and C. elegans. (A) The LEC and POD across the 11 assays are plotted for the 12 FRCs (–log₁₀ (value/1000,000)) with the higher the value, the more potent. (B) The 11 assays are broken up into 3 screening outcomes (developmental toxicity, developmental neurotoxicity, and acute neurotoxicity) and the LEC/POD expressed in μM is listed per FRC class. Dash (−) represents no toxicity observed at the tested concentrations. NT denotes FRCs not tested in certain assays. For the zebrafish behavior assay, the values in the bracket represent the phase the LEC/POD was calculated.

Expression Data

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Antibody Labeling

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Acknowledgments

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Reprinted from Reproductive toxicology (Elmsford, N.Y.), 96, Truong, L., Marvel, S., Reif, D.M., Thomas, D., Pande, P., Dasgupta, S., Simonich, M.T., Waters, K.M., Tanguay, R.L., The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity, 359-369, Copyright (2020) with permission from Elsevier. Full text @ Reprod. Toxicol.