FIGURE

Fig. 2

ID

ZDB-FIG-221030-46

Publication

Zheng et al., 2021 - Molecular basis for bipartite recognition of histone H3 by the PZP domain of PHF14

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Fig. 2

Crystal structure of PHF14_PZP in a peptide-free state. (A) Wall-eye stereo view of the overall structure of free PHF14_PZP. PHD1 (cyan), ZnK (light blue), PHD2 (light pink), and α-helix (white) are shown as ribbons. Zinc ions are depicted as spheres. Red dotted lines indicate the invisible insertion loop. Key secondary structural elements are labeled. (B) Structural alignment of PHF14_PZP (magenta), AF10_PZP (green) and BRPF1_PZP (white). (C) Interactions between the C-terminal α-helix with PHD1 (left) and PHD2 (right). Key residues are shown as sticks. Hydrogen bonds are shown as green dashes with distances labeled in Å. (D) Structural alignment of PHF14_PHD1 (cyan) and PHF14_PHD2 (light pink). Note that the insertion loop is topologically equivalent to the β-hairpin tower.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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