FIGURE

Fig. 8

ID

ZDB-FIG-220914-113

Publication

Zhang et al., 2022 - GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway

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Fig. 8

TMEM251/GCAF deficiency leads to defects in M6P modification of lysosomal enzymes at the cis-Golgi. Lysosomal enzymes without M6P are targeted to the secretory pathway, resulting in lysosome dysfunction.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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