FIGURE
Fig. 4
- ID
- ZDB-FIG-220818-17
- Publication
- Arena et al., 2022 - Transforming growth factor-beta signaling modulates perineurial glial bridging following peripheral spinal motor nerve injury in zebrafish
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Fig. 4
Phagocytosis is observed in perineurial glia with inhibition of TGFβ. (a,b) Representative images of 5 dpf nkx2.2a:megfp;olig2:dsred injured larvae treated with either 1% DMSO (a) or 10 μM SB431542 (b) at 3 hpi. The dashed circle indicates the injury site. Axonal debris and perineurial glial vesicles are specified by blue arrows. 3D renderings of these representative images are shown in both a 0° and 90° rotated views (Imaris). (c) Quantification of the presence of phagocytic vesicles in 1% DMSO or 10 μM SB431542 in 1% DMSO-treated larvae. Phagocytic vesicles were present in 100% of injured nerves in both groups (n = 5 nerves in 4 larvae, 6 nerves in 4 larvae, respectively). Scale bars, 25 μm; magnified insets and 3D renderings, 10 μm.
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Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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