FIGURE

Fig. 5

ID

ZDB-FIG-220715-53

Publication

Berger et al., 2022 - Mob4-dependent STRIPAK involves the chaperonin TRiC to coordinate myofibril and microtubule network growth

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Fig. 5

Mob4 interacts with TRiC.

(A) As depicted in transmission electron micrographs, the sarcomere organisation detected in siblings was compromised in single cct3^sa1761 homozygotes as well as cct3^sa1761;mob4^geh compound homozygotes. Electron-dense aggregates (arrowhead) as found in cct3^sa1761 homozygotes were absent in cct3^sa1761;mob4^geh compound homozygotes (n = 3 per genotype). Scale bar sizes are 2 μm. (B) After rescaling to siblings (100 ± 1%), the birefringence of cct3^sa1761;mob4^geh compound homozygotes (31.4 ± 0.6%) was significantly ameliorated compared to single cct3^sa1761 homozygotes (22.7 ± 0.3%). Crosses represent averaged birefringence of clutches with a minimum of 4 larvae per genotype (n = 5 clutches). Data are presented as mean ± SEM; *** P < 0.001 by one-way ANOVA with post hoc Tukey’s test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cct3^{sa1761/sa1761} cct3^{sa1761/sa1761}; mob4^pc43/pc43
Observed In:	skeletal muscle cell sarcomere organization
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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