FIGURE

Fig. 4

ID

ZDB-FIG-220627-15

Publication

Lee et al., 2022 - FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease

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Fig. 4

Fmnl2 knock-down reduces the number of activated microglia and alters the amyloid load. a–f dIHCs for L-plastin (microglia) and kdrl:GFP with DAPI counterstain on control morpholino (a, b), Aβ42+ control morpholino (c, d), and Aβ42+ fmnl2a/b morpholino (e, f) injected brains. a′, b′, c′ L-plastin channel alone. g Quantification graph for the number of activated microglia in the indicated conditions. h High magnification images from three blood vessels in Aβ42+ control morpholino-injected zebrafish brains (left column) and Aβ42+ fmnl2a/b morpholino-injected brains (right column). Scale bars as indicated

Expression Data

Gene:	EGFP
Antibody:	Ab5-app
Fish:	s843Tg (AB) s843Tg + MO1-fmnl2a + MO1-fmnl2b (AB)
Condition:	chemical treatment by injection: amyloid-beta polypeptide 42
Knockdown Reagents:	MO1-fmnl2a MO1-fmnl2b
Anatomical Terms:	telencephalon telencephalon blood vessel telencephalon endothelial cell
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s843Tg (AB) s843Tg + MO1-fmnl2a + MO1-fmnl2b (AB)
Condition:	chemical treatment by injection: amyloid-beta polypeptide 42
Knockdown Reagents:	MO1-fmnl2a MO1-fmnl2b
Observed In:	telencephalon telencephalon amyloid-beta polypeptide 42 telencephalon microglial cell
Stage:	Adult

Phenotype Detail

Acknowledgments

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