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Fig. 5

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ZDB-FIG-220520-13

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Wang et al., 2022 - Polygoni multiflori radix extracts inhibit SARS-CoV-2 pseudovirus entry in HEK293T cells and zebrafish larvae

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Fig. 5

PMR_water and PMR_EtOH inhibit the entry of SARS-CoV-2 PEG-pseudovirus in zebrafish. Larvae at 3 dpf were pre-treated with (A) PMR_water or (B) PMR_EtOH, then co-treated with the respective extract and SARS-CoV-2 PEG-pseudovirus for a further 72 h. PCR amplification of whole larval cDNA showed the relative level of Luc expression in the treatment and control groups (left). The relative level of Luc expression was quantified by normalization to the expression level of g6pd (right). The data show that treatment with PMR_water or PMR_EtOH inhibited the expression of Luc (and thus the entry of PEG-pseudovirus) in larvae. The data represent the mean ± SD (n = 4), and statistical differences were tested using the 2-sample ttest, ****p < 0.0001.

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Reprinted from Phytomedicine : international journal of phytotherapy and phytopharmacology, 102, Wang, X., Lin, S., Tang, R.W., Lee, H.C., Chan, H.H., Choi, S.S.A., Leung, K.W., Webb, S.E., Miller, A.L., Tsim, K.W., Polygoni multiflori radix extracts inhibit SARS-CoV-2 pseudovirus entry in HEK293T cells and zebrafish larvae, 154154, Copyright (2022) with permission from Elsevier. Full text @ Phytomedicine