ZFIN ID: ZDB-FIG-220516-45
Zou et al., 2022 - A High-Fat Diet Induces Muscle Mitochondrial Dysfunction and Impairs Swimming Capacity in Zebrafish: A New Model of Sarcopenic Obesity. Nutrients   14(9) Full text @ Nutrients
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Antibodies:
Fish:
Condition:
Anatomical Term:
Stage: Adult
PHENOTYPE:
Fish:
Condition:
Observed In:
Stage: Adult

Fig. 5

Figure 5. Long-term HFD feeding induced abnormal mitochondrial fusion and fission. (A,B) Protein expression of OPA1, MFN2, and DRP1. (C) Representative photomicrographs of muscle sections imaged using transmission electron microscopy. M, mitochondria. *, p < 0.05, **, p < 0.01. Data represent means, and error bars represent standard errors of the means. Scale bar in transmission electron microscopy images, 0.5 μm. ND, normal diet; HFD, high-fat diet.

Gene Expression Details No data available
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab2-mfn2 WB AB high fat Adult skeletal muscle
Ab4-opa1 WB AB high fat Adult skeletal muscle
Phenotype Details
Fish Conditions Stage Phenotype
AB high fat Adult skeletal muscle Ab2-mfn2 labeling decreased amount, abnormal
Adult skeletal muscle Ab4-opa1 labeling decreased amount, abnormal
Adult skeletal muscle mitochondrial crista broken, abnormal
Adult skeletal muscle mitochondrion degenerate, abnormal
Adult skeletal muscle mitochondrion swollen, abnormal
Acknowledgments:
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