FIGURE

Figure 3

ID

ZDB-FIG-220427-25

Publication

Hesaraki et al., 2022 - A Novel Missense Variant in Actin Binding Domain of MYH7 Is Associated With Left Ventricular Noncompaction

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Figure 3

Expression patterns of all MYH superfamily members during cardiac development. (A) Differential expression pattern of MYH7 in the mouse heart during 12 stages of development indicates that the expression of this gene plays an important role in the mouse cardiogenesis, especially during embryonic life. (B) Modeling scheme of the protein-protein interaction between native MYH7/actin and MYH7 p.Leu655Met/actin at the surface. Actin in the wild-type position is shown in green and in the mutant position, is shown in red. (C) Secondary structure cartoon representation. Actin in the wild-type position is shown in green, and in the mutant position, is shown in red. (D) The Leu655Met mutation is highlighted. Wild MYH7 protein (Leu 655) is shown in green, and the protein that has the mutated residue (Met 655) is shown in red.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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