FIGURE

Fig. 1.

ID

ZDB-FIG-220411-15

Publication

Crilly et al., 2022 - Zebrafish drug screening identifies candidate therapies for neuroprotection after spontaneous intracerebral haemorrhage

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Fig. 1.

The drug screen resulted in 150 compounds that prevented brain cell death in a model of ICH. (A) Schematic of the screening protocol. (B) Structural similarities, based on MACCS keys, between the 150 positive hits represented by a radial tree. The six highlighted compounds were identified as predicted to be efficacious in cardiovascular disease. hpi, h post-injury; ICH, intracerebral haemorrhage; MACCS, Molecular Access System. Scale bars: 100 μm.

Expression Data

Gene:	Venus
Fish:	arhgef7b^m292/m292; mq8Tg
Condition:	physical alteration: brain
Anatomical Term:	brain
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	arhgef7b^m292/m292; mq8Tg
Condition:	physical alteration: brain
Observed In:	brain brain apoptotic process locomotory behavior
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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