FIGURE

Figure 1—figure supplement 1.

ID

ZDB-FIG-220314-73

Publication

Qi et al., 2022 - Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish

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Figure 1—figure supplement 1.

Endocardial protrusions in the ventricle are mostly located in the outer curvature and are close to delaminating or trabecular cardiomyocytes (CMs).

(A) Quantification of the direction of endocardial protrusions; most endocardial protrusions extend toward the myocardium. (B) Quantification of the average number of endocardial protrusions in the ventricle and atrium. (C–D) Confocal projection images of the heart of Tg(myl7:mCherry-CAAX); Tg(cdh5:Gal4ff); Tg(UAS:LIFEACT-GFP) zebrafish at 60 (C) and 72 (D) hours post-fertilization (hpf). Arrows point to endocardial protrusions; arrowheads point to delaminating CMs and trabecular CMs close to endocardial protrusions. (E) Quantification of the percentage of endocardial protrusions in the outer curvature of the ventricle. (F) Quantification of the percentage of endocardial protrusions in close proximity to delaminating CMs or trabecular CMs. (G) Quantification of the percentage of delaminating CMs or trabecular CMs in close proximity to endocardial protrusions. de CM, delaminating CM; TL CM, trabecular layer CM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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