FIGURE

Fig. 3

ID

ZDB-FIG-220113-2

Publication

Mullapudi et al., 2019 - Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

sFlt1 expression in β-cells severely impairs their function. (A-C) Confocal projection images of the vasculature (white) in 120 hpf Tg(fli:GFP) larvae, in combination with the indicated transgenic line. Yellow dashed lines outline the pancreas. A′-C′ show the endothelial cells. (A″-C″) Confocal planes of β-cells (red) and the surrounding vasculature (white) in 120 hpf Tg(fli:GFP) larvae, in combination with the indicated transgenic line. (D) Percentage of β-cells responsive to physiological (−Glucose) and exogenous (+Glucose) glucose, measured as visual fluctuations in fluorescence in 120 hpf Tg(ins:GCaMP5) larvae, n=5-17 animals. (E) Glucose levels in 120 hpf animals, n=4-6 replicates, 10 animals per replicate. Data are mean±s.e.m; individual data points are shown. P-values from t-tests are presented. A, anterior; D, dorsal.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development