FIGURE

Figure 6

ID

ZDB-FIG-211002-151

Publication

Li et al., 2021 - Functions of SMC2 in the Development of Zebrafish Liver

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Figure 6

Activation of the p53-dependent apoptotic pathway contributed to the small liver phenotype in SMC2^−/− mutants. (A) Phenotype comparison of WT, SMC2^−/− and SMC2^−/−/p53^−/− embryos under the Tg (fabp10a:dsRed;ela3l:EGFP) transgenic background at 72 hpf and 96 hpf. (B) WT embryos, SMC2^−/− and SMC2^−/−/p53^−/− embryos stained with the fabp10a probe at 96 hpf. (C) TUNEL analysis of apoptotic cells in the liver of SMC2^−/−/p53^−/− mutants compared to WT and SMC2^−/− mutants at 96 hpf under the Tg (fabp10a:dsRed;ela3l:EGFP) transgenic background. Scale bar, 50 μm. (D) Quantitative analysis of the apoptotic cells in the liver. Fluorescence intensities of three WT embryos, three SMC2^−/− mutant embryos and three SMC2^−/−/p53^−/− embryo across the liver were determined using the ImageJ software. **, p < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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