FIGURE

FIGURE 6

ID

ZDB-FIG-210929-18

Publication

Liu et al., 2021 - Social Deficits and Repetitive Behaviors Are Improved by Early Postnatal Low-Dose VPA Intervention in a Novel shank3-Deficient Zebrafish Model

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FIGURE 6

Increased grm5 expression level in shank3-deficient zebrafish upon early VPA treatment. (A,B) Quantitative immunoblot blot analysis showed that the expression level of neuron protein NeuN was not significantly restored in the brain of shank3ab^{– /–} zebrafish treated with VPA relative to WT zebrafish (2 mpf). Similarly, the expressions of post-synaptic homer1 protein (C,D) and presynaptic synaptophysin protein (E,F) were not significantly increased in in the brain of shank3ab^{– /–} zebrafish treated with VPA relative to WT zebrafish (2 mpf). (G) The relative mRNA expression levels of grm1a, grm1b, and grm5a at 4.5 mpf were detected. Each group n = 3. Data are shown as mean ± SEM. *P < 0.05, **P < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Neurosci.