FIGURE

Figure 4.

ID
ZDB-FIG-210911-43
Publication
Partoens et al., 2021 - Modelling neurodevelopmental disorders and epilepsy caused by loss of function of kif2a in zebrafish
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Figure 4.

kif2a−/− larvae show increased susceptibility to epilepsy. a, Visual representation of the setup of local field potential recording from optic tectum (indicated in red) of 5 dpf larvae. b, Number of seizures and average seizure duration in kif2a+/+ and kif2a−/− larvae. c, Number of seizures and average seizure duration in kif2a+/+ and kif2a−/− larvae after 6 mm PTZ immersion for 15 min. d, Representative fragments of a 10 min recording (calibration: 0.1 mV, 20 s) of kif2a+/+ and kif2a−/− larvae after 6 mm PTZ immersion for 15 min, with enlargement of a polyspiking event (calibration: 0.02 mV, 2 s) in kif2a−/− larvae. Data are represented as the mean ± SD. Significant values are noted as **p ≤ 0.01. No increased seizure susceptibility was observed in the brains of kif2a−/− zebrafish larvae from +/– incrosses (Extended Data Fig. 4-1).
Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Condition:
Observed In:
Stage: Day 5

Phenotype Detail
Acknowledgments
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