FIGURE

Fig. 5

ID

ZDB-FIG-210729-21

Publication

Li et al., 2021 - Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome

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Fig. 5

Behavioral antiepileptic activity of (+)-FFA (A), (−)-FFA (B), (+)-norFFA (C) and (−)-norFFA (D) in the zebrafish scn1Lab^−/− mutant model, and ( ±)-FFA (colored in blue, A–D), used as a positive control. (A–D) Locomotor activity of larvae pre-exposed to different concentration of enantiomers of FFA and norFFA for 22 h. Data were assessed over the total tracking period of 10 min and expressed as cm/100 s. Results were pooled from 3–4 independent experiments, with 67–75 larvae for each VHC-treated group, and 21–28 larvae for each compound-treated group. Statistical analysis: one-way ANOVA with Dunnett’s multiple comparison test. Significance levels: ^*p ≤ 0.05, ^**p ≤ 0.01, ^***p ≤ 0.001, ^****p ≤ 0.0001. WT wild type, VHC vehicle, FFA fenfluramine, norFFA norfenfluramine

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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