FIGURE

Fig. 3

ID

ZDB-FIG-210729-19

Publication

Li et al., 2021 - Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

Behavioral (A, D, G) and electrophysiological (B, C, E, F, H, I) antiepileptic activity of combination treatment (colored in blue) of valproate (VPA) with stiripentol (STP) (A–C), (±) fenfluramine [(±)-FFA] (D–F), and cannabidiol (CBD) (G–I) in the zebrafish scn1Lab^−/− mutant model. (A, D, G) Locomotor activity of larvae pre-exposed to antiepileptic drugs (AEDs) for 22 h. Data were assessed over the total tracking period of 10 min and expressed as cm/100 s. Results were pooled from 3–4 independent experiments, with 120 larvae for each of the VHC-treated groups, and 20–30 larvae for each AED-treated group. (B, C, E, F, H, I) Noninvasive local field potential (LFP) recordings from the optic tectum of larvae pre-exposed to antiepileptic drugs (AEDs) for 22 h. Epileptiform discharges are quantified by the cumulative duration (mean ± SEM) (B, E, H) and frequency (mean ± SEM) (C, F, I) of events per 10-min recording. With 23 larvae for the VHC-treated group, 12–14 larvae for each AED-treated group. Statistical analysis: one-way ANOVA with Dunnett’s multiple comparison test (locomotor assay), Kruskal–Wallis testing with Dunn’s multiple comparisons (LFP measurements). Significance levels: ^*p ≤ 0.05, ^**p ≤ 0.01, ^***p ≤ 0.001, ^****p ≤ 0.0001. WT wild type, VHC vehicle

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Neurochem. Res.