FIGURE

Fig. 4

ID

ZDB-FIG-210725-17

Publication

Wang et al., 2021 - Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis

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Fig. 4

Loss of puma rescues mdm2-null induced apoptosis at early embryonic stage.

A Anti-active Caspase-3 staining on 12, 15, 18, and 21 hpf mdm2^+/+ and mdm2^−/− zebrafish embryos. B qRT-PCR analysis of puma and noxa in 15 hpf mdm2^+/+, mdm2 siblings (mdm2+/+ and mdm2^+/−) and mdm2^−/− zebrafish embryos. n = 3 from ~30 pooled embryos per sample. Bars represent mean ± SEM. **p < 0.01. C Anti-active Caspase-3 staining on 12, 15, 18, and 21 hpf mdm2^+/+ bbc3^−/− and mdm2^−/− bbc3^−/− zebrafish embryos. D Gross images of 15, 18, and 21 hpf mdm2^+/+, mdm2^−/−, and mdm2^−/− bbc3^−/− zebrafish embryos.

Expression Data

Genes:	bbc3 pmaip1
Antibody:	Ab1-casp3
Fish:	WT mdm2^uab9/uab9
Anatomical Term:	whole organism
Stage Range:	5-9 somites to 20-25 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mdm2^uab9/uab9 bbc3^uab4/uab4; mdm2^uab9/uab9
Observed In:	whole organism whole organism apoptotic process
Stage Range:	5-9 somites to 20-25 somites

Phenotype Detail

Acknowledgments

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