FIGURE

FIGURE 4

ID

ZDB-FIG-210403-10

Publication

Moreau et al., 2021 - Deciphering DSC2 arrhythmogenic cardiomyopathy electrical instability: From ion channels to ECG and tailored drug therapy

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FIGURE 4

Spontaneous electrical activity of control and patient‐specific hiPSC‐CM. (A) Raw traces illustrating the recording of spontaneous electrical activity (action potentials, AP) of control (left) and patient‐specific (right) hiPSC‐CM. (B–I) AP parameters were evaluated for both control (N = 41) and ACM patient‐specific (N = 45) hiPSC‐CM: (B) AP rate, (C) maximum diastolic potential, (D) maximum depolarization slope, (E) AP Amplitude, (F) AP duration at 20% of repolarization (APD₂₀,), (G) APD₅₀, (H) APD₉₀ and (I) the APD₉₀ corrected using Bazett's formula. Histograms represent the median (95% confidence interval). The horizontal grey area illustrates the difference between the control and the patient‐specific conditions. ***p < 0.001 and ****p < 0.0001 (Mann–Whitney test)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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