ZFIN ID: ZDB-FIG-210126-22
Lee et al., 2019 - Evolutionarily conserved regulation of sleep by epidermal growth factor receptor signaling. Science advances   5:eaax4249 Full text @ Sci Adv
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Antibody:
Fish:
Conditions:
Anatomical Terms:
Stage Range: Protruding-mouth to Days 21-29
PHENOTYPE:
Fish:
Conditions:
Observed In:
Stage Range: Protruding-mouth to Days 21-29

Fig. 5 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
GCaMP ct871Tg; ct872Tg control Protruding-mouth to Days 21-29 neuron IFL
ct871Tg; ct872Tg heat shock Protruding-mouth to Days 21-29 neuron IFL
ct872Tg control Protruding-mouth to Days 21-29 neuron IFL
ct872Tg standard conditions Protruding-mouth to Days 21-29 neuron IFL
ct872Tg chemical treatment: gefitinib Protruding-mouth to Days 21-29 neuron IFL
Tomato ct871Tg; ct872Tg control Protruding-mouth to Days 21-29 neuron IFL
ct871Tg; ct872Tg heat shock Protruding-mouth to Days 21-29 neuron IFL
ct872Tg control Protruding-mouth to Days 21-29 neuron IFL
ct872Tg standard conditions Protruding-mouth to Days 21-29 neuron IFL
ct872Tg chemical treatment: gefitinib Protruding-mouth to Days 21-29 neuron IFL
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab1-npvf IHC WT control Protruding-mouth - Days 21-29 hypothalamus
IHC WT chemical treatment: gefitinib Protruding-mouth - Days 21-29 hypothalamus
IHC ct871Tg heat shock Protruding-mouth - Days 21-29 hypothalamus
Phenotype Details
Fish Conditions Stage Phenotype
WT chemical treatment: gefitinib Protruding-mouth - Days 21-29 hypothalamus Ab1-npvf labeling decreased amount, abnormal
WT chemical treatment: RF9 Protruding-mouth - Days 21-29 sleep decreased process quality, abnormal
ct871Tg heat shock Protruding-mouth - Days 21-29 hypothalamus Ab1-npvf labeling increased amount, abnormal
ct871Tg; ct872Tg heat shock Protruding-mouth - Days 21-29 neuron GCaMP expression increased amount, abnormal
Protruding-mouth - Days 21-29 neuron Tomato expression increased amount, abnormal
ct872Tg chemical treatment: gefitinib Protruding-mouth - Days 21-29 neuron GCaMP expression decreased amount, abnormal
Protruding-mouth - Days 21-29 neuron Tomato expression decreased amount, abnormal
egfract870/+ standard conditions Protruding-mouth - Days 21-29 sleep decreased process quality, abnormal
egfract870/+ chemical treatment: RF9 Protruding-mouth - Days 21-29 sleep decreased process quality, abnormal
egfract870/ct870 standard conditions Protruding-mouth - Days 21-29 sleep decreased process quality, abnormal
egfract870/ct870 chemical treatment: RF9 Protruding-mouth - Days 21-29 sleep decreased process quality, abnormal
npvfct845/+ standard conditions Protruding-mouth - Days 21-29 sleep normal process quality, normal
npvfct845/+ heat shock Protruding-mouth - Days 21-29 sleep normal process quality, normal
npvfct845/+; ct871Tg standard conditions Protruding-mouth - Days 21-29 sleep normal process quality, normal
npvfct845/+; ct871Tg heat shock Protruding-mouth - Days 21-29 sleep increased process quality, abnormal
npvfct845/ct845 standard conditions Protruding-mouth - Days 21-29 sleep normal process quality, normal
npvfct845/ct845 heat shock Protruding-mouth - Days 21-29 sleep normal process quality, normal
npvfct845/ct845; ct871Tg standard conditions Protruding-mouth - Days 21-29 sleep normal process quality, normal
npvfct845/ct845; ct871Tg heat shock Protruding-mouth - Days 21-29 sleep increased process quality, abnormal
Full text @ Sci Adv