ZFIN ID: ZDB-FIG-201209-5
Podobnik et al., 2020 - Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fish. Nature communications   11:6230 Full text @ Nat. Commun.
Observed In:
Stage: Adult

Fig. 4 Mutant phenotypes in <italic>D. rerio</italic>, <italic>D. aesculapii</italic> and their hybrids of genes required for heterotopic interactions.

In D. rerio mutations in, a, Cx39.4 (luchs), b, Cx41.8 (leopard), and c, Igsf11 (seurat) lead to spotted patterns, whereas, d, mutations in Kcnj13 (obelix) result in fewer and wider stripes. In D. aesculapii, eh, mutations in the orthologous genes lead to the complete loss of any pattern. In D. rerio dominant alleles of Kcnj13, i, cause broader stripes and irregularities when heterozygous. Double mutants, j, Cx39.4 k.o.; Kcnj13 k.o., loose almost all melanophores and pattern. Interspecific hybrids between D. rerio and D. aesculapii, which are both mutant, k, for Cx41.8, or, l, for Kcnj13, show patterns of spots or wider stripes similar to the corresponding D. rerio mutants (b, d; n = 15). All images show representative examples of the corresponding genotypes. Scale bars correspond to 1 mm.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
gja4t37ui/t37ui standard conditions Adult pigment cell (sensu Vertebrata) spotted, abnormal
gja4t37ui/t37ui; kcnj13txg6/txg6 standard conditions Adult melanocyte absent, abnormal
gja5bt1/t1 standard conditions Adult pigment cell (sensu Vertebrata) spotted, abnormal
igsf11t35ui/t35ui standard conditions Adult pigment cell (sensu Vertebrata) spotted, abnormal
kcnj13txg6/+ standard conditions Adult melanophore stripe decreased amount, abnormal
Adult melanophore stripe increased width, abnormal
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