PUBLICATION

Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fish

Authors
Podobnik, M., Frohnhöfer, H.G., Dooley, C.M., Eskova, A., Nüsslein-Volhard, C., Irion, U.
ID
ZDB-PUB-201208-39
Date
2020
Source
Nature communications   11: 6230 (Journal)
Registered Authors
Frohnhöfer, Hans Georg, Irion, Uwe, Nüsslein-Volhard, Christiane, Podobnik, Marco
Keywords
none
MeSH Terms
  • Animals
  • Chromatophores/metabolism
  • Color*
  • Evolution, Molecular
  • Hybridization, Genetic
  • Phenotype
  • Pigmentation/genetics*
  • Potassium Channels, Inwardly Rectifying/genetics*
  • Species Specificity
  • Zebrafish/classification
  • Zebrafish/genetics*
  • Zebrafish Proteins/genetics*
PubMed
33277491 Full text @ Nat. Commun.
Abstract
The genetic basis of morphological variation provides a major topic in evolutionary developmental biology. Fish of the genus Danio display colour patterns ranging from horizontal stripes, to vertical bars or spots. Stripe formation in zebrafish, Danio rerio, is a self-organizing process based on cell-contact mediated interactions between three types of chromatophores with a leading role of iridophores. Here we investigate genes known to regulate chromatophore interactions in zebrafish that might have evolved to produce a pattern of vertical bars in its sibling species, Danio aesculapii. Mutant D. aesculapii indicate a lower complexity in chromatophore interactions and a minor role of iridophores in patterning. Reciprocal hemizygosity tests identify the potassium channel gene obelix/Kcnj13 as evolved between the two species. Complementation tests suggest evolutionary change through divergence in Kcnj13 function in two additional Danio species. Thus, our results point towards repeated and independent evolution of this gene during colour pattern diversification.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes