FIGURE

Figure 4

ID

ZDB-FIG-201130-70

Publication

Küssau et al., 2020 - Functional Characterization of the N-Acetylmuramyl-l-Alanine Amidase, Ami1, from Mycobacterium abscessus

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Figure 4

Characterization of Ami1_Mab inhibitors. (A) Chemical structure of the three compounds selected by thermal-shift assay. Chloride atom is in green, carbon in black, oxygen in red and nitrogen in blue (B) Melting curves of Ami1_Mab in the presence of compound 1 (blue) at 244 μM, compound 2 (red) at 879 μM, and compound 3 (blue) at 845 μM as compared with protein incubated with 5% DMSO (black). (C) Assessment of Ami1_Mab inhibition by compounds 1, 2, and 3 by TLC. (D) Evaluation of the Ami1_Mab activity over an acidic pH range.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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