FIGURE

Fig. 4

ID

ZDB-FIG-200914-8

Publication

Mizoguchi et al., 2020 - Transient activation of the Notch-her15.1 axis plays an important role in the maturation of V2b interneurons

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Fig. 4

her15.1 was expressed in V2b interneurons under Notch signaling. (A) Statistical analysis of her 15.1 expression patterns in V2 neuron pairs. The expression patterns correspond to the expression criteria detailed in Fig. S4A. (B) Representative her15.1 expression patterns in V2 neuron pairs. (C) Expression of her15.1 and tal1 in V2 neuron pairs at 19 ss. (D) her15.1WT, but not her15.1ΔWRPW, exhibited induced tal1 expression in both V2 neuron pairs. (E) her15.1WT overexpression affected axon outgrowth. The magenta dotted lines show the shape of V2 linage interneurons. (F) Data analysis of E. (G) Hypothetical model of V2a and V2b interneuron differentiation and maturation. Notch signaling is transiently activated in the V2b progenitor and induces her15.1. her15.1 might activate downstream genes and direct to V2b fate. After V2b fate determination, Notch signaling is downregulated and the V2b cell matures.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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