FIGURE

Figure 6—figure supplement 1.

ID
ZDB-FIG-200907-26
Publication
Wertman et al., 2020 - The identification of dual protective agents against cisplatin-induced oto-and nephrotoxicity using the zebrafish model
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Figure 6—figure supplement 1.

Dopamine and L-mimosine do not protect cancer cell lines from cisplatin-induced death 24 hr following cisplatin treatment.

Neuroblastoma (NBL) and oral squamous cell carcinoma cell lines were pretreated for 12 hr vehicle control, or either dopamine or L-mimosine at either 0.01 mM or 0.03 mM. Cells were then treated with increasing concentrations of cisplatin and incubated for 24 hr (48 hr data shown in Figure 6a-f). An alamarBlue assay was used to determine cell viability. Results are displayed as % compared to untreated control. (A and D) LAN5, (B and E) SK-N-AS, (C and F) HSC-3. *=p<0.05, **=p<0.01, ***=p<0.005, and ****=p<0.001, as per two-way ANOVA with a Tukey post-test. N=3.

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