FIGURE

Fig. 2

ID

ZDB-FIG-200903-11

Publication

Schumacher et al., 2020 - Integrin α5 and Integrin α4 cooperate to promote endocardial differentiation and heart morphogenesis

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Fig. 2

Fig. 2. itga5 mutant embryos have endocardial defects. (A, B) Sibling and itga5 mutant embryos at 28 hpf. (C, D) Sibling and itga5 mutant embryos at 48 hpf. Lateral views, arrowheads indicate pericardial edema that is visible in itga5 mutants at both stages. Scale bar is 200 μm. (E–H) nfatc1 expression analyzed by ISH is reduced to varying degrees in the endocardium of itga5 mutants compared to siblings. (I–K) kdrl expression is normal in the itga5 mutant endocardium, but the morphology of the endocardium is abnormal compared to siblings. Arrowheads indicate endocardium. Embryos in E-K are at 28 hpf, dorsal views.

Expression Data

Genes:	kdrl nfatc1
Fish:	WT itga5^tbfe1/tbfe1
Anatomical Term:	endocardium
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	itga5^tbfe1/tbfe1
Observed In:	endocardial ring endocardium pericardial region
Stage Range:	Prim-5 to Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 465(1), Schumacher, J.A., Wright, Z.A., Owen, M., Bredemeier, N.O., Sumanas, S., Integrin α5 and Integrin α4 cooperate to promote endocardial differentiation and heart morphogenesis, 46-57, Copyright (2020) with permission from Elsevier. Full text @ Dev. Biol.