FIGURE

Figure 2

ID

ZDB-FIG-200820-2

Publication

Bryant et al., 2020 - Diverse species-specific phenotypic consequences of loss of function sorting nexin 14 mutations

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Figure 2

Homozygous Snx14 mutation causes embryonic lethality in mice. (A) Viable Snx14^KO/KO embryos are not detected at Mendelian ratios at E10.5 and no Snx14^KO/KO mice were found at P0. (B) Snx14^KO/KO weighed less than their Snx14^WT/WT and Snx14^WT/KO littermates. Bars = Mean ± SD, *p < 0.05, **p < 0.01, one-way ANOVA. (C) Snx14^KO/KO embryos appear smaller, without clear vascularisation in the head (insets). (D) Surface visualisation of Snx14^WT/WT and Snx14^KO/KO embryos with optical projection tomography. (E) Internal visualisation of Snx14^WT/WT and Snx14^KO/KO embryos with high resolution episcopic microscopy (HREM).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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