FIGURE

Fig 7

ID

ZDB-FIG-200620-15

Publication

Ang et al., 2020 - Midkine-a functions as a universal regulator of proliferation during epimorphic regeneration in adult zebrafish

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Fig 7

Summary diagram: The function of Midkine-a during epimorphic regeneration.

(A,B) Following fin amputation, Midkine-a regulates proliferation of precursors produced from dedifferentiation of osteoblasts and activation of mesenchymal stem and progenitors (A). Following extraocular muscle excision, Midkine-a regulates proliferation of precursor produced from dedifferentiation of myocyte (B). During fin and muscle regeneration, loss of Midkine-a results in diminished initial burst of proliferation. (C) During regeneration of retinal neurons, Midkine-a governs proliferation of dedifferentiated Müller glia. In the absence of Midkine-a, retinal neurons fail to regenerate.

Expression Data

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Acknowledgments

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