FIGURE

Fig. s1

ID

ZDB-FIG-200611-30

Publication

Santos-Ledo et al., 2020 - Alternative splicing of jnk1a in zebrafish determines first heart field ventricular cardiomyocyte numbers through modulation of hand2 expression

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Fig. s1

Full peptide sequences of duplicated zebrafish jnk1a and jnk1b inferred from transcripts and compared with human JNK1. Black text indicates identical amino acids, green text indicates favourable amino acid substitutions and red text divergent amino acid residues. Exons 2–6 and 9–12 are common to all transcripts and highly conserved. Both jnk1a and jnk1b genes are capable of producing exon 7 and short C-terminus containing transcripts that fully match human JNK1 transcripts. However, whilst Ex8 derived from jnk1b matches the human peptide the Ex8 from jnk1a is divergent and contains a serine rather than threonine residue (*). In contrast whilst the long C-terminal extension provided by jnk1a matches the human, the jnk1b long terminal extension is highly divergent and differs by 9/39 amino acids including insertion of an additional threonine residue.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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