FIGURE

Fig 8

ID

ZDB-FIG-200429-14

Publication

Arribat et al., 2020 - Spastin mutations impair coordination between lipid droplet dispersion and reticulum

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Fig 8

Spastin depletion modifies lipid profile in adult zebrafish brain and skeletal muscle.

(A-B) Unesterified cholesterol (Chol), total esterified cholesterol (Est Chol) and total triacylglycerides (Tot TG) in brain (A) and in muscle (B). (C) Fatty acids composed of C16 in muscle. (D-E) Ceramides (Cer) in brain (D) and muscle (E). (F) Phosphatidylethanoamines (PE) in brain. All values correspond to lipid quantity per total protein amount. Bars are mean ± SEM (n = 3 per group), #P<0.08, *P<0.05, P<0.01, ***P<0.001 (unpaired t‐test between Ctrl and Spa-/-). See also S1 Table.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	spast^ula1/ula1
Observed In:	brain cholesterol brain N-docosanoylsphingosine brain N-hexacosanoylsphingosine brain N-hexacosenoylsphingosine brain N-hexadecanoylsphingosine brain N-icosanoylsphingosine brain N-octadecanoylsphingosine brain N-tetracosanoylsphingosine brain N-tetracosenoylsphingosine brain phosphatidylethanolamine 32:0 brain phosphatidylethanolamine 32:1 zwitterion brain phosphatidylethanolamine 34:0 zwitterion brain phosphatidylethanolamine 34:1 zwitterion brain phosphatidylethanolamine 36:1 zwitterion brain phosphatidylethanolamine 36:2 zwitterion brain phosphatidylethanolamine 36:3 zwitterion brain phosphatidylethanolamine 36:4 zwitterion brain phosphatidylethanolamine 38:2 zwitterion brain phosphatidylethanolamine 38:3 zwitterion brain phosphatidylethanolamine 38:4 zwitterion brain phosphatidylethanolamine 38:5 zwitterion brain phosphatidylethanolamine 38:6 zwitterion brain phosphatidylethanolamine 40:3 zwitterion brain phosphatidylethanolamine 40:5 zwitterion brain phosphatidylethanolamine 40:6 zwitterion brain phosphatidylethanolamine 40:7 zwitterion brain triglyceride skeletal muscle cholesterol skeletal muscle cholesteryl ester skeletal muscle hexadecanoic acid skeletal muscle hexadecatrienoic acid skeletal muscle N-docosanoylsphingosine skeletal muscle N-hexacosanoylsphingosine skeletal muscle N-hexacosenoylsphingosine skeletal muscle N-hexadecanoylsphingosine skeletal muscle N-icosanoylsphingosine skeletal muscle N-octadecanoylsphingosine skeletal muscle N-tetracosanoylsphingosine skeletal muscle N-tetracosenoylsphingosine skeletal muscle triglyceride
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.