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ZDB-FIG-200414-15

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Lleras-Forero et al., 2019 - Zebrafish and medaka as models for biomedical research of bone diseases

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Fig. 2

Mouse and zebrafish mutants for Abcc6 and Enpp1 recapitulate some of the over-mineralization seen in Pseudoxanthoma elasticum (PXE) patients. a) PXE patients present areas of mineralization in the skin (taken from the American Osteopathic College of Dermatology). b) Mouse mutants for Enpp1 develop joint stiffness and contractures. In addition, mineralization has been found in the heart and circulatory system, retina and kidneys (Li et al., 2013) (image taken from (Li et al., 2013)). c) Zebrafish mutants for abcc6, resembling human PXE patients in the mineralization in the skin (image taken from (Mackay et al., 2015)).

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Reprinted from Developmental Biology, 457(2), Lleras-Forero, L., Winkler, C., Schulte-Merker, S., Zebrafish and medaka as models for biomedical research of bone diseases, 191-205, Copyright (2019) with permission from Elsevier. Full text @ Dev. Biol.