ZFIN ID: ZDB-PUB-190724-15
Zebrafish and medaka as models for biomedical research of bone diseases
Lleras-Forero, L., Winkler, C., Schulte-Merker, S.
Date: 2019
Source: Developmental Biology   457(2): 191-205 (Review)
Registered Authors: Schulte-Merker, Stefan, Winkler, Christoph
Keywords: none
MeSH Terms:
  • Animals
  • Biomedical Research
  • Bone Diseases/genetics*
  • Bone Diseases/physiopathology*
  • Disease Models, Animal
  • Genome/genetics
  • Oryzias/genetics*
  • Whole Genome Sequencing
  • Zebrafish/genetics*
PubMed: 31325453 Full text @ Dev. Biol.
The identification of disease-causing mutations has in recent years progressed immensely due to whole genome sequencing approaches using patient material. The task accordingly is shifting from gene identification to functional analysis of putative disease-causing genes, preferably in an in vivo setting which also allows testing of drug candidates or biotherapeutics in whole animal disease models. In this review, we highlight the advances made in the field of bone diseases using small laboratory fish, focusing on zebrafish and medaka. We particularly highlight those human conditions where teleost models are available.