|ZFIN ID: ZDB-PUB-190724-15|
Zebrafish and medaka as models for biomedical research of bone diseases
Lleras-Forero, L., Winkler, C., Schulte-Merker, S.
|Source:||Developmental Biology 457(2): 191-205 (Review)|
|Registered Authors:||Schulte-Merker, Stefan, Winkler, Christoph|
|PubMed:||31325453 Full text @ Dev. Biol.|
Lleras-Forero, L., Winkler, C., Schulte-Merker, S. (2019) Zebrafish and medaka as models for biomedical research of bone diseases. Developmental Biology. 457(2):191-205.
ABSTRACTThe identification of disease-causing mutations has in recent years progressed immensely due to whole genome sequencing approaches using patient material. The task accordingly is shifting from gene identification to functional analysis of putative disease-causing genes, preferably in an in vivo setting which also allows testing of drug candidates or biotherapeutics in whole animal disease models. In this review, we highlight the advances made in the field of bone diseases using small laboratory fish, focusing on zebrafish and medaka. We particularly highlight those human conditions where teleost models are available.
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