(A) Immunostaining for GFAP (red) and GFP after transplantation of astroglia transduced with Lv-UbiC:GFP into wild type mouse cortex. (B) Immunostaining for OLIG2 (red) and GFP after transplantation of astroglia transduced with Lv-UbiC:GFP into wild type mouse cortex. (C) Immunostaining for GFP after transplantation of astroglia transduced with Lv-UbiC:GFP into adult mouse cortex shows neuronal morphologies. (D) Immunostaining for GFP after transplantation of astroglia transduced with Lv-UbiC:STAT6VT-GFP into adult mouse cortex. (E) Immunostaining for OLIG2 (red) and GFP after transplantation of astroglia transduced with Lv-UbiC:STAT6VT-GFP into wild type mouse cortex. (F) Immunostaining for GFAP (red) and GFP after transplantation of astroglia transduced with Lv-UbiC:STAT6VT-GFP into wild type mouse cortex. (G) Immunostaining for GFAP (orange) and GFP after transplantation of astroglia transduced with Lv-UbiC:GFP into APP/PS1dE9 adult mouse cortex. (H) Immunostaining for GFAP (orange) and GFP after transplantation of astroglia transduced with Lv-UbiC:STAT6VT-GFP into APP/PS1dE9 adult mouse cortex. n = 3 animals. Schematic information on injection locations presented in the insets. Scale bars: 50 μm.
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