FIGURE

Fig. 3

ID
ZDB-FIG-200319-34
Publication
Collins et al., 2019 - Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model
Other Figures
All Figure Page
Back to All Figure Page
Fig. 3

Mitochondrial and metabolic changes in pitx2c−/− adult atria. (A) Quantification of relative mtDNA content in pitx2c+/+ and pitx2c−/− atria by qPCR. (B) Representative image of mitochondrial clusters (highlighted in green) observed in pitx2c−/− adult hearts by TEM (n = 3). (C) qPCR of known PITX2 targets as well as additional metabolic genes in pitx2c+/+ and pitx2c−/− adult atria. Significant down-regulation of cox7c, ppargc1a, foxo1a, pparaa, ucp1, and prdx5 mRNA levels and up-regulation of hcn4 and esrra as well as adipogenic genes fabp11a, adipor2, and zbtb16b mRNA levels are observed in pitx2c−/− atria (C). Error bars correspond to SEM. *P < 0.05 by unpaired t test; **P < 0.01 by unpaired t test.

Expression Data
Genes: (all 16)
Fish:
Anatomical Term:
Stage: Adult

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: Adult

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.