FIGURE

Fig. 2.

ID

ZDB-FIG-200116-2

Publication

Rissone et al., 2019 - A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2.

Reduced hair cell number and secondary neuromast differentiation phenotypes in ak2^hg14 mutants. (A) Alkaline phosphatase staining of 3-5 dpf ak2^hg14 homozygous embryos and their siblings (WT). White arrowheads indicate the migrating secondary primordium (primII). L1-2 and LII.1-3 designate primary and secondary neuromasts, respectively. Scale bars: 50 μm. (B,C) Yo-PRO-1 iodide staining of hair cells (HCs) in lateral line neuromasts in ak2^hg14 embryos and their wild-type siblings during development to compare the average number of HCs in LII.1 secondary neuromasts (B) and in primary neuromasts (C). (D) Average number of HCs per primary neuromast in Yo-PRO-1 iodide-stained ak2^hg14 embryos and their siblings 2 days after ablation with CuSO₄. Mean±s.d.**P<0.0011; ****P<0.0001 (unpaired, two-tailed Student's t-test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ak2^hg14/hg14
Condition:	chemical ablation: hair cell, chemical treatment by environment: copper(II) sulfate
Observed In:	posterior lateral line neuromast hair cell regenerating tissue neuromast hair cell
Stage Range:	Protruding-mouth to Day 6

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.