FIGURE

Fig. 4

ID

ZDB-FIG-191230-656

Publication

Wu et al., 2019 - EFTUD2 gene deficiency disrupts osteoblast maturation and inhibits chondrocyte differentiation via activation of the p53 signaling pathway

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Fig. 4

Zebrafish subjected to eftud2 gene knockout had aberrant cartilage and bone development. a, c Lateral view of larvae treated with eftud2 TALEN mRNA (−/−) at 3 dpf and 5 dpf, exhibiting disruption of cartilage and bone formation compared with WT (+/+). b, d Ventral view of larvae treated with eftud2 TALEN mRNA (−/−) at 3 dpf and 5 dpf, showing cartilage and bone hypoplasia and otolith loss compared with WT (+/+). (The images on the left are WT controls, and those on the right are eftud2 mutants. Black arrows indicate the jawbone. a’ Meckel’s bone. b’ Ceratohyal bone. c’ Parasphenoid. d’ Notochord. e’ Otolith. f’ Ceratobranchial 1–5)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + TALEN2-eftud2 + TALEN3-eftud2 + TALEN4-eftud2
Knockdown Reagents:	TALEN2-eftud2 TALEN3-eftud2 TALEN4-eftud2
Observed In:	ceratohyal cartilage embryonic viscerocranium morphogenesis ethmoid cartilage inner ear Meckel's cartilage otolith otolith formation
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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