Figure 2
- ID
- ZDB-FIG-191230-1164
- Publication
- Joseph et al., 2018 - Disease-Associated Mutations in CEP120 Destabilize the Protein and Impair Ciliogenesis
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JS (V194A) and JATD (A199P) Mutations in Human CEP120 Cause Subtle Changes in the C2B Domain Structure (A) Per-residue plot of the weighted chemical shift perturbations of the human CEP120 C2B V194A (left) and A199P mutant (right) relative to the WT protein observed in 1H,15N BEST-TROSY NMR spectra at 20°C. Gray bars indicate line-broadened peaks. (B) Molecular surface representation of the (C) Homology model of human CEP120 C2B as ribbon representation. The weighted chemical-shift perturbations of the human CEP120 C2B V194A (left) and A199P mutant (right) relative to the WT protein as observed in (A) are plotted color-coded onto this model. See also |