FIGURE

Fig. S1

ID

ZDB-FIG-191018-4

Publication

Espenschied et al., 2019 - Epithelial delamination is protective during pharmaceutical-induced enteropathy

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Fig. S1

Quantification of Acridine Orange stained lumenal material and response of Tg(ubb:seca5-tdTomato) larvae to Glafenine exposure.

(A) Brightfield and fluorescence images (range indicator lookup table and grayscale) of DMSO and Glafenine treated larvae from a representative experiment (li =liver; sb = swim bladder; b = intestinal bulb; y = yolk; nm = neuromast).

(B) Representative AO line scan fluorescence traces for larvae shown in (A).

(C) Scatter dot plot of integrated intestinal AO from the same experiment in a [the points colored red correspond to the larvae shown in (A)]. Significance determined by unpaired two-sided Student’s t-test.

(D) Cumulative frequency distribution plot of data from (C) fit with 3-parameter least squares regression (significance was determined by extra-sum-of-squares F-test, rejecting the null hypothesis that one curve would fit both datasets).

(E,F) Images of Tg(ubb:seca5-tdTomato)xt24 DMSO- and Glafenine-treated 6 dpf larvae and quantification (each dot corresponds to an individual larva). Significance was determined by unpaired two-sided Student’s t-test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA