FIGURE

Figure 1

ID

ZDB-FIG-190723-2159

Publication

van der Weyden et al., 2016 - Cross-species models of human melanoma

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Figure 1

Established melanoma pathways. The two major signalling pathways implicated in melanoma are the mitogen‐activated protein kinase and the phosphatidylinositol‐4,5‐bisphosphate 3‐kinase pathways, which are in red and green, respectively. Key genes include c‐KIT (pink), CDK (blue), GNAQ/GNA11 (brown), MITF (orange), NRAS (yellow), and P53/BCL (purple). MC1R, which is involved in skin pigmentation, and TERT and POT1, which are involved in telomere regulation, are also shown. This figure was modified from Vidwans et al142 under the Creative Commons Attribution License. The lines shown indicate known interactions between pathways or molecules.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Pathol.