FIGURE

Figure 2

ID
ZDB-FIG-190723-1845
Publication
Martin et al., 2015 - Cellular and molecular mechanisms of repair in acute and chronic wound healing
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Figure 2

Chronic wound biology. Chronic wounds are often infected and exhibit a persistent aberrant inflammatory profile. Re-epithelialization stalls but wound keratinocytes are hyperproliferative. Granulation tissue is defective and does not nurture healing, in part due to elevated matrix metalloproteases (MMPs) and poor fibroblast infiltration. Neoangiogenesis is poor and fibrin cuffs restrict existing vessels, limiting the diffusion of oxygen through the wound, rendering the wound hypoxic.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Br. J. Dermatol.