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Figure 2

ID
ZDB-IMAGE-190723-1865
Source
Figures for Martin et al., 2015
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Figure Caption

Figure 2

Chronic wound biology. Chronic wounds are often infected and exhibit a persistent aberrant inflammatory profile. Re-epithelialization stalls but wound keratinocytes are hyperproliferative. Granulation tissue is defective and does not nurture healing, in part due to elevated matrix metalloproteases (MMPs) and poor fibroblast infiltration. Neoangiogenesis is poor and fibrin cuffs restrict existing vessels, limiting the diffusion of oxygen through the wound, rendering the wound hypoxic.

Acknowledgments
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